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- Title
Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer.
- Authors
Chang, Wen–Wei; Hu, Fang–Wei; Yu, Cheng–Chia; Wang, Hsiu–Huan; Feng, Hsiang–Pu; Lan, Chih; Tsai, Lo–Lin; Chang, Yu–Chao
- Abstract
Background Previously, we enriched a subpopulation of head and neck cancer-derived tumor initiating cells (HNC-TICs) presented high tumorigenic, chemo-radioresistant, and coupled with epithelial-mesenchymal transition (EMT) properties. The purpose of this study was to investigate the therapeutic effect and molecular mechanisms of quercetin on HNC-TICs. Method ALDH1 activity of head and neck cancer cells with quercetin treatment was assessed by the Aldefluor assay flow cytometry analysis. Self-renewal, invasiveness, and EMT capability of HNC-TICs with different doses of quercetin was presented. Results We first observed that the treatment of quercetin significantly downregulated the ALDH1 activity of head and neck cancer cells in a dose-dependent manner ( p < .05). Moreover, quercetin reduced self-renewal property and stemness signatures expression in head and neck cancer-derived sphere cells. The migration ability of head and neck cancer-derived sphere cells was lessened under quercetin treatment partially due to the decreased productions of Twist, N-cadherin, and vimentin. Conclusion Quercetin suppressing HNC-TICs characteristics may therefore be valuable therapeutics clinically in combination with standard treatment modalities. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects
QUERCETIN; HEAD &; neck cancer treatment; CANCER cell proliferation; WESTERN immunoblotting; FIBROBLASTS; METASTASIS
- Publication
Head & Neck, 2013, Vol 35, Issue 3, p413
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.22982