We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association of p16<sup>INK4a</sup> overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue.
- Authors
Harris, Stephen L.; Thorne, Leigh B.; Seaman, William T.; Neil Hayes, D.; Couch, Marion E.; Kimple, Randall J.
- Abstract
Background The aim of this study was to examine biomolecular profiles in a cohort of young adults with squamous cell cancers (SCCs) of the oral tongue. Methods We identified all patients aged 18 to 39 years diagnosed with SCC of the oral tongue at our institution. Immunohistochemical (IHC) staining was performed for p16INK4a, epidermal growth factor receptor (EGFR), phosphorylated-EGFR (pEGFR), p53, and ERCC1. Human papillomavirus (HPV) testing was performed using in situ hybridization (ISH) and polymerase chain reaction (PCR). Biomarker expression and HPV status were correlated with outcomes. Results We identified 25 patients with sufficient tumor samples. Median age at diagnosis was 30 years (range, 20-39 years). p16INK4a overexpression was observed in 11 of 25 patients, whereas HPV-16 positivity was observed in none of the tumor samples by ISH and 2 of the tumor samples by PCR. p16INK4a positivity was correlated with improved relapse-free survival (hazard ratio [HR] = 0.23, p = .01) and overall survival (HR = 0.28, p = .05). Neither EGFR, pEGFR, p53, nor excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1) expression correlated with outcome on univariate analysis. Conclusions p16INK4a overexpression was common and was a marker of favorable prognosis. p16INK4a overexpression was not a reliable predictor of HPV positivity in our cohort. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
- Subjects
COHORT analysis; SQUAMOUS cell carcinoma; ORAL cancer diagnosis; IMMUNOHISTOCHEMISTRY techniques; STAINS &; staining (Microscopy); EPIDERMAL growth factor; STATISTICAL correlation; PHYSIOLOGY; PATIENTS
- Publication
Head & Neck, 2011, Vol 33, Issue 11, p1622
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21650