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- Title
Body composition in infants with chronic lung disease after treatment with dexamethasone.
- Authors
Bolt, R J; Van Weissenbruch, M M; Roos, J C; Delemarre-Van De Waal, H A; Cranendonk, A; Lafeber, H N
- Abstract
<bold>Unlabelled: </bold>The aim of this study was to study the effect of chronic lung disease (CLD) and dexamethasone treatment on body composition in preterm infants (birthweight < 1500 g). In addition, anthropometric measurement of body composition were compared with dual-energy X-ray absorptiometry (DXA). Fourteen preterm infants with CLD and a comparison group of 18 preterm infants were studied until 3 mo corrected age. CLD infants received approximately 20 kcal kg-1 per day extra nutritional intake during dexamethasone treatment until term. At term no differences were found between CLD and no CLD infants for percentage bone mass (1.4 +/- 0.2 vs 1.4 +/- 0.1%), fat mass (18.7 +/- 4.5 vs 17.4 +/- 3.5%), lean body mass (79.9 +/- 4.6 vs 81.2 +/- 3.5%) or bone mineral density (0.15 +/- 0.02 vs 0.15 +/- 0.01%). At 3 mo corrected age both groups were also similar for bone mass (1.6 +/- 0.1 vs 1.6 +/- 0.2%), fat mass (22.6 +/- 5.5 vs 24.5 +/- 5.7%), lean body mass (75.8 +/- 5.7 vs 74.0 +/- 5.8%) and bone mineral density (0.20 +/- 0.02 vs 0.20 +/- 0.01%). All anthropometric measurements showed a high correlation with body composition. However, calculated fat mass was 56.7 +/- 8.8% lower than fat mass measured with DXA.<bold>Conclusion: </bold>Body composition at term and 3 mo corrected age in preterm infants treated with dexamethasone for CLD, who received extra caloric intake until term, did not differ from that in preterm infants without CLD.
- Subjects
HUMAN body composition; LUNG diseases; PREMATURE infant diseases; ANTHROPOMETRY; BODY composition; GLUCOCORTICOIDS; HUMAN growth; NONPARAMETRIC statistics; ANALYSIS of variance; PHOTON absorptiometry; DEXAMETHASONE; CASE-control method; INGESTION; REGRESSION analysis; BRONCHOPULMONARY dysplasia; BONE density; LONGITUDINAL method; PHARMACODYNAMICS
- Publication
Acta Paediatrica, 2002, Vol 91, Issue 7, p815
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1080/08035250213220