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- Title
Living-related-donor kidney transplantation outcome in recipients with primary focal-segmental glomerulosclerosis.
- Authors
Refaie, Ayman; Sobh, Mohamed; Moustafa, Fatma; Bakr, Mohamed A.; El-Mekresh, M.; Farahat, S.; Ghoneim, Mohamed A.; Refaie, A; Sobh, M; Moustafa, F; Bakr, M A; Ghoneim, M A
- Abstract
We studied the outcome of renal transplantation in 30 patients with primary focal-segmental glomerulosclerosis (FSGS) and in 30 controls in whom renal failure was secondary to nonglomerular renal diseases. All patients received living-related-donor kidneys, and the majority had one-haplotype HLA matching. Within the follow-up period, the mean serum creatinine values were significantly higher in FSGS recipients as compared with the control group (p = 0.02). However, the frequency of acute rejection episodes and the mean blood pressure values were not significantly different between the two groups. There was a tendency of a higher incidence of proteinuria among FSGS recipients in comparison with the controls. Moreover, nephrotic-range proteinuria occurred only in 3 recipients of the FSGS group. Recurrence of FSGS was morphologically documented in 2 recipients 7 and 18 months, respectively, after transplantation. It is concluded that FSGS as the primary disease has a negligible impact on the living-related-donor kidney transplantation in the Egyptian population. Therefore, this disease should not discourage transplantation for this group of patients.
- Publication
American Journal of Nephrology, 1999, Vol 19, Issue 1, p55
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000013426