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- Title
Neither interleukin-4 receptor α expression on CD4<sup>+</sup> T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis.
- Authors
Michels, Chesney E.; Scales, Hannah E.; Saunders, Karin A.; McGowan, S.; Brombracher, Frank; Alexander, James; Lawrence, Catherine E.
- Abstract
The T helper type 2 (Th2) mediated expulsion of the gastrointestinal nematode Trichinella spiralis requires interleukin-4 receptor α (IL-4Rα) expression on both bone-marrow-derived and non-bone-marrow-derived cells. To more definitively investigate the role of IL-4/IL-13 responsiveness in the development of protective immunity to T. spiralis, cell-specific IL-4Rα signalling on CD4+ T cells (Lckcre IL-4Rα−/flox) and macrophages/neutrophils (LysMcre IL-4Rα−/flox) was analysed on the BALB/c background. Infection of wild-type and control IL-4Rα−/flox mice induced a Th2-type immune response with elevated IL-4 cytokine production, parasite-specific immunoglobulin G1 (IgG1), total IgE, intestinal mastocytosis and enteropathy. In contrast, global IL-4Rα-deficient BALB/c mice showed reduced worm expulsion, antibody production, intestinal mastocytosis and gut pathology. BALB/c mice generated with cell-specific deletion of IL-4Rα on CD4+ T lymphocytes or macrophages/neutrophils, controlled gastrointestinal helminth infection by eliciting a protective immune response comparable to that observed with wild-type and IL-4Rα−/flox controls. Together, this shows that the development of host protective Th2 responses accompanied by parasite loss is independent of IL-4Rα expression on CD4+ T cells and macrophages/neutrophils.
- Subjects
TRICHINELLA spiralis; INTERLEUKIN-4; T cells; BONE marrow; LYMPHOCYTES; IMMUNOGLOBULINS
- Publication
Immunology, 2009, Vol 128, Issue 1pt2, pe385
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2008.02987.x