We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil.
- Authors
Maia, Carlos R.; Stella, Steffan F.; Wagner, Flavia; Pianca, Thiago G.; Krieger, Fernanda V.; Cruz, Luciane N.; Polanczyk, Guilherme V.; Rohde, Luis A.; Polanczyk, Carísi A.
- Abstract
Objective: To perform a cost-utility analysis on the treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate immediate-release (MPH-IR) in children and adolescents from Brazil. Method: A Markov model was constructed to compare MPH-IR vs. no treatment. A 24-week naturalistic study was conducted to collect transition probabilities and utility data. Effectiveness was expressed as quality-adjusted life-years (QALY), and costs reported in 2014 international dollars (l$). The perspective was the Brazilian Unified Health System as payer, and the time horizon was 6 years. Results: Of 171 patients, 73 provided information at baseline, and 56 at week 24. Considering the MPH-IR monthly cost of l$ 38, the incremental cost-effectiveness ratio (ICER) of treatment was l$ 9,103/QALY for children and l$ 11,883/QALY for adolescents. In two-way sensitivity analysis, considering one Gross National Product per capita (l$ 11,530) as willingness-to-pay, a cost of no-treatment lower than l$ 45/month would render MPH-IR a cost-saving strategy. Discussion: MPH-IR treatment of children and adolescents is cost-effective for ADHD patients from the Brazilian public health system perspective. Both patients and the healthcare system might benefit from such a strategy. Trial registration number: NCT01705613.
- Subjects
TREATMENT of attention-deficit hyperactivity disorder; METHYLPHENIDATE; ADOLESCENT psychopathology; ATTENTION-deficit hyperactivity disorder; CHILDREN with attention-deficit hyperactivity disorder; SENSITIVITY analysis; DRUG prices; THERAPEUTICS
- Publication
Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria, 2016, Vol 38, Issue 1, p30
- ISSN
1516-4446
- Publication type
Article
- DOI
10.1590/1516-4446-2014-1516