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- Title
Identification and Evaluation of Free Radical Scavenging Activity of Quinolizidine Alkaloids Isolated from Various Parts of Anagyris foetida Plant.
- Authors
Aliboudhar, Hamza; Tigrine-Kordjani, Nacéra; Lakache, Zineb
- Abstract
Anagyris foetida is a genus of legumes belonging to the Fabaceae family, considered as a good source of medications to treat various ailments. In order to determine the biological potential of this plant, the present work deals for the first time with the extraction and identification of alkaloids from leaves, stems and seeds of Algerian A. foetida species and evaluation of their antioxidant effects. The extraction was performed by three different methods to compare the influence of many factors (extraction temperature, nature and polarity of solvents) on the yield and chemical composition of extracts. Capillary GC-MS analyses of the obtained fractions allowed the identification of six alkaloids in the leaves and stems and five in the seeds, with a significant difference in the percentage content of identified compounds. The identified alkaloids include sparteine, N-methylcytisine, cytisine, 5,6-dehydrolupanine, lupanine and anagyrine. In vitro antioxidant activity of the alkaloids extracts was assessed by DPPH free radical scavenging test. Results showed that different parts of A. foetida exhibited relatively moderate scavenging of DPPH radicals. Extracts obtained by method III presented the highest antioxidant activity with IC50 = 108.7 ± 9.0 μg/mL for the leaves and stems and 92.9 ± 6.2 μg/mL for the seeds. These results suggested that cytisine, which was extracted only by method III in both samples, presented the highest antiradical activity.
- Subjects
FREE radicals; CHEMICAL yield; SPARTEINE; AMARYLLIDACEAE; LEGUMES; CYTISINE; GAS chromatography/Mass spectrometry (GC-MS); ALKALOIDS
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 56, Issue 7, p966
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02734-8