We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysis.
- Authors
Keller, Andreas; Backes, Christina; Gerasch, Andreas; Kaufmann, Michael; Kohlbacher, Oliver; Meese, Eckart; Lenhof, Hans-Peter
- Abstract
Motivation: Deregulated signaling cascades are known to play a crucial role in many pathogenic processes, among them are tumor initiation and progression. In the recent past, modern experimental techniques that allow for measuring the amount of mRNA transcripts of almost all known human genes in a tissue or even in a single cell have opened new avenues for studying the activity of the signaling cascades and for understanding the information flow in the networks.
- Subjects
ALGORITHMS; TUMORS; THERAPEUTICS; GENE expression; COMPUTATIONAL biology
- Publication
Bioinformatics, 2009, Vol 25, Issue 21, p2787
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btp510