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- Title
Predicting pathway membership via domain signatures.
- Authors
Holger Fröhlich; Mark Fellmann; Holger Sültmann; Annemarie Poustka; Tim Beißbarth
- Abstract
Motivation: Functional characterization of genes is of great importance for the understanding of complex cellular processes. Valuable information for this purpose can be obtained from pathway databases, like KEGG. However, only a small fraction of genes is annotated with pathway information up to now. In contrast, information on contained protein domains can be obtained for a significantly higher number of genes, e.g. from the InterPro database. Results: We present a classification model, which for a specific gene of interest can predict the mapping to a KEGG pathway, based on its domain signature. The classifier makes explicit use of the hierarchical organization of pathways in the KEGG database. Furthermore, we take into account that a specific gene can be mapped to different pathways at the same time. The classification method produces a scoring of all possible mapping positions of the gene in the KEGG hierarchy. Evaluations of our model, which is a combination of a SVM and ranking perceptron approach, show a high prediction performance. Moreover, for signaling pathways we reveal that it is even possible to forecast accurately the membership to individual pathway components. Availability: The R package gene2pathway is a supplement to this article. Contact: h.froehlich@dkfz-heidelberg.de Supplementary Information: Supplementary data are available at Bioinformatics online.
- Subjects
INFORMATION science; COMPUTERS in biology; ARTIFICIAL intelligence; BIOINFORMATICS
- Publication
Bioinformatics, 2008, Vol 24, Issue 19, p2137
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btn403