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- Title
Synthesis of Fluorine-Containing 2-(1-Aryl-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetic Acids.
- Authors
Fokin, A. S.; Burgart, Ya. V.; Saloutin, V. I.; Chupakhin, O. N.
- Abstract
Acid hydrolysis of ethyl 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetates gives 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2,2-dihydroxyacetic acids which undergo dehydration on heating in toluene to afford 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetic acids. Reactions of the latter with excess morpholine result in replacement of two fluorine atoms in positions 5 and 7 by the amine residues.
- Subjects
ACETATES; HYDROLYSIS; CARBOXYLIC acids; AROMATIC compounds; ORGANIC cyclic compounds; ORGANIC synthesis; ORGANOFLUORINE compounds
- Publication
Russian Journal of Organic Chemistry, 2005, Vol 41, Issue 9, p1374
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1007/s11178-005-0349-x