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- Title
Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome.
- Authors
Vijverberg, Everard G.B.; Dols, annemiek; Krudop, Welmoed a.; Peters, anne; Kerssens, Cora J.; van Berckel, Bart N.M.; Wattjes, Mike P.; Barkhof, Frederik; Gossink, Flora; Prins, Niels D.; Stek, Max L.; Scheltens, Philip; Pijnenburg, Yolande a.L.
- Abstract
Background/Aims: We aimed to prospectively assess the diagnostic accuracy of the revised criteria for behavioural variant frontotemporal dementia (bvFTD) among subjects presenting with a frontal lobe syndrome in middle-late adulthood. Methods: Patients were included based on a predominant behavioural clinical presentation, a Frontal Behavioural Inventory (FBI) score of ≥ 11 and/or a Stereotypy Rating Inventory (SRI) score of ≥ 10. At baseline, the fulfilment of the international consensus criteria for behavioural variant FTD (FTDC) was systematically recorded. The 2-year follow-up consensus diagnosis was used as the gold standard to calculate sensitivity and specificity of the FTDC criteria for possible and probable bvFTD. Results: Two-year follow-up data were available for 116 patients (85%). Two-year follow- up consensus diagnoses consisted of probable/definite bvFTD (n = 27), other dementia (n = 30), psychiatric disorders (n = 46) and other neurological disorders (n = 13). Sensitivity for possible bvFTD was 85% (95% CI 70-95%) at a specificity of 27% (95% CI 19-37%). Sensitivity for probable bvFTD was 85% (95% CI 69-95%), whereas their specificity was 82% (95% CI 73-89%). Conclusions: We found a good diagnostic accuracy for FTDC probable bvFTD. However, the specificity for FTDC possible bvFTD was low . Our results reflect the symptomatic overlap between bvFTD, other neurological conditions and psychiatric disorders, and the relevance of adding neuroimaging to the diagnostic process.
- Subjects
DIFFERENTIAL diagnosis; LONGITUDINAL method; MENTAL status examination; PSYCHOLOGICAL tests; DESCRIPTIVE statistics; FRONTOTEMPORAL dementia; SYMPTOMS; DIAGNOSIS
- Publication
Dementia & Geriatric Cognitive Disorders, 2016, Vol 41, Issue 3/4, p210
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000444849