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- Title
Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines.
- Authors
Ding, Yuxin; Ma, Renchao; Hider, Robert C.; Ma, Yongmin
- Abstract
A facile and general synthesis of 2,4,6‐triaryl pyrimidines has been developed. It involves a one‐pot [2+1+1+1+1] pseudo five‐component annulation of one methyl ketone, two aldehydes and two NH4OAc catalyzed by TfOH. One C−C and four C−N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.
- Subjects
PYRIMIDINE synthesis; ANNULATION; METHYL ketones; PYRIMIDINES; FUNCTIONAL groups; STRUCTURAL frames
- Publication
Asian Journal of Organic Chemistry, 2020, Vol 9, Issue 2, p242
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201900700