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- Title
Recommendations of Polish HCV Expert Group and Polish Society of Haematologists and Transfusiologists on diagnosis and treatment of HCV-infected hemato-oncology patients.
- Authors
Piekarska, Anna; Flisiak, Robert; Pawłowska, Małgorzata; Jaroszewicz, Jerzy; Gil, Lidia; Giebel, Sebastian; Hus, Iwona; Lech-Marańda, Ewa; Tomasiewicz, Krzysztof
- Abstract
Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease. About 70% of infections lead to chronic hepatitis, which is associated with a risk of cirrhosis within 20 years in 15-30% of patients. A vaccine against hepatitis C is still not available, but directly-acting antiviral drugs allow eradication of the virus in more than 95% of those infected. HCV infection is particularly dangerous in patients with cancer, including proliferative hematological diseases. This is because patients chronically infected with HCV can develop exacerbations of hepatitis during oncological treatment, making therapy much more difficult to manage and thus adversely affecting prognosis. In addition, HCV infection plays an important role in the development of certain subtypes of B-cell non-Hodgkin lymphoma (NHL), such as marginal zone lymphoma, diffuse large cell lymphoma, and Waldenström macroglobulinemia. Antiviral treatment leads to a hematological response in 60-75% of patients with HCV-associated indolent NHL. This article presents epidemiological data on HCV infection in hematooncological patients, as well as recommendations on methods of diagnosis and principles of treatment of the infection in hematooncological patients, including patients with lymphomas associated with HCV infection.
- Subjects
MUCOSA-associated lymphoid tissue lymphoma; HEPATITIS C vaccines; CHRONIC active hepatitis; HEPATITIS C virus; HEPATITIS C; BLOOD diseases; DIFFUSE large B-cell lymphomas
- Publication
Acta Haematologica Polonica, 2024, Vol 55, Issue 1, p2
- ISSN
0001-5814
- Publication type
Article
- DOI
10.5603/ahp.97936