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- Title
Nocardiosis in tropical renal transplant recipients.
- Authors
John, George T; Shankar, Viswanathan; Abraham, Abi M; Mathews, Mary S; Thomas, Paulose P; Jacob, Chakko K
- Abstract
Background: The epidemiology of nocardiosis in the tropics among renal transplant recipients has not been reported. Methods: An evaluation of nocardiosis for 30 yr in one of the large transplant centres in South Asian region. Results: Of the 1968 patients who received primary renal allografts at Christian Medical College & Hospital, 27 patients developed nocardiosis over 30 yr. Early nocardiosis (≤ 2 yr) was associated with chronic liver disease and the use of cyclosporin (CsA) as compared with its later occurrence (>2 yr). Seventeen patients (63%) had two or more associated post-transplant infections, of whom 10 had tuberculosis. Mortality in these patients was associated with chronic liver disease. Conclusions: Nocardiosis manifests earlier (<2 yr) in CsA treated patients who have chronic liver disease. Among renal transplant recipients of the tropics nocardiosis is a marker of a high susceptibility to tuberculosis and other infections, the association with tuberculosis is stronger in those developing early nocardiosis (<2 yr). Chronic liver disease is a risk factor for death in patients with nocardiosis especially when associated with tuberculosis. This report constitutes the largest single centre experience among renal transplant recipients.
- Subjects
KIDNEY transplantation; PATIENTS; COMPLICATIONS from organ transplantation
- Publication
Clinical Transplantation, 2002, Vol 16, Issue 4, p285
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1034/j.1399-0012.2002.01145.x