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- Title
Hypericum caprifoliatum (Guttiferae) Cham. & Schltdl.: a species native to South Brazil with antidepressant-like activity.
- Authors
Viana, Alice F.; Rego, Jean-Claude do; Munari, Leonardo; Dourmap, Nathalie; Heckler, Ana Paula; Costa, Teresa Dalla; von Poser, Gilsane L.; Costentin, Jean; Rates, Stela M.K.
- Abstract
In this work, previously published and unpublished results on biological activity of Hypericum caprifoliatum, a native specie to South Brazil, are presented. Lipophilic extracts obtained from this species showed an antidepressant-like activity in mice and rat forced swimming test. Results from in vivo experiments suggest an effect on the dopaminergic transmission. Besides that, in vitro experiments demonstrated that the extract and its main component (a phloroglucinol derivative) inhibit monoamine uptake in a concentration-dependent manner, more potently to dopamine, but this effect is not related to direct binding at the uptake sites. It was also observed that a 3-day treatment with lipophilic extract prevents stress-induced corticosterone rise in mice frontal cortex but not in plasma. The lipophilic and methanolic H. caprifoliatum extracts also demonstrated antinociceptive effect, which seems to be indirectly mediated by the opioid system. These results indicate that H. caprifoliatum presents a promising antidepressant-like effect in rodents which seems to be related to a mechanism different from that of other classes of antidepressants.
- Subjects
SOUTH Brazil; HYPERICUM; DRUG lipophilicity; ANTIDEPRESSANTS; DOPAMINERGIC neurons; OPIOIDS
- Publication
Fundamental & Clinical Pharmacology, 2006, Vol 20, Issue 6, p507
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/j.1472-8206.2006.00440.x