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- Title
Translational Mini-Review Series on Immunology of Vascular Disease: Mechanisms of vascular inflammation and remodelling in systemic vasculitis.
- Authors
Maugeri, N.; Rovere-Querini, P.; Baldini, M.; Sabbadini, M. G.; Manfredi, A. A.
- Abstract
Vessel walls are the primary inflammatory sites in systemic vasculitides. In most cases the initiating event is unknown, and a self-sustaining circuit attracts and activates inflammatory leucocytes in the wall of vessels of various size and anatomical characteristics. Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury.
- Subjects
VASCULAR diseases; INFLAMMATORY mediators; VASCULITIS; LEUCOCYTE motility; BLOOD platelet activation; VASCULAR endothelial growth factors; TISSUE wounds
- Publication
Clinical & Experimental Immunology, 2009, Vol 156, Issue 3, p395
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/j.1365-2249.2009.03921.x