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- Title
Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachytherapy for tracheal cancer
- Authors
Kazuma Kobayashi; Naoya Murakami; Koji Inaba; Akihisa Wakita; Satoshi Nakamura; Hiroyuki Okamoto; Jun Sato; Rei Umezawa; Kana Takahashi; Hiroshi Igaki; Yoshinori Ito; Naoyuki Shigematsu; Jun Itami
- Abstract
Purpose: Small organ subvolume irradiated by a high-dose has been emphasized to be associated with late complication after radiotherapy. Here, we demonstrate a potential use of surface-based, non-rigid registration to investigate how high-dose volume topographically correlates with the location of late radiation morbidity in a case of tracheobronchial radiation stenosis. Material and methods: An algorithm of point set registration was implemented to handle non-rigid registration between contour points on the organ surfaces. The framework estimated the global correspondence between the dose distribution and the varying anatomical structure. We applied it to an 80-year-old man who developed tracheobronchial stenosis 2 years after high-dose-rate endobronchial brachytherapy (HDR-EBT) (24 Gy in 6 Gy fractions) and external beam radiotherapy (EBRT) (40 Gy in 2 Gy fractions) for early-stage tracheal cancer. Results and conclusions: Based on the transformation function computed by the non-rigid registration, irradiated dose distribution was reconstructed on the surface of post-treatment tracheobronchial stenosis. For expressing the equivalent dose in a fractional dose of 2 Gy in HDR-EBT, α/β of linear quadratic model was assumed as 3 Gy for the tracheal bronchus. The tracheobronchial surface irradiated by more than 100 Gyαβ3 tended to develop severe stenosis, which attributed to a more than 50% decrease in the luminal area. The proposed dose reconstruction technique can be a powerful tool to predict late radiation toxicity with spatial consideration.
- Subjects
IRRADIATION; RADIOTHERAPY; TRACHEAL diseases; CANCER treatment; RADIOISOTOPE brachytherapy
- Publication
Journal of Contemporary Brachytherapy, 2016, Vol 8, Issue 2, p156
- ISSN
1689-832X
- Publication type
Article
- DOI
10.5114/jcb.2016.59688