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- Title
Neoadjuvant Chemotherapy in Breast Cancer: Evaluation of the Impact on Surgical Outcomes and Prognosis.
- Authors
Chiappa, Corrado; Greta, Maltecca; Miriam, Leoni; Ietto, Giuseppe; Inversini, Davide; Ballabio, Andrea; Bonetti, Alice; Mangano, Alberto; Gueli, Rossana; Carcano, Giulio; Rovera, Francesca Angela
- Abstract
Simple Summary: Neoadjuvant treatment is an increasingly used treatment option for patients with both advanced and early-stage breast cancer to achieve downstaging and to improve prognosis. Therefore, it is important to evaluate its role in the multidisciplinary management of breast cancer patients and its effects on surgical outcomes and disease-free and overall survival. Achieving a pathologic complete response seems to improve disease-free and overall survival and even a partial response can be useful as an in-vivo chemosensitivity test for tailored adjuvant therapy. Clinical features, histology, and immunohistochemical findings play a role in achieving a pathological response. Therefore, they should be thoroughly investigated beforehand to better evaluate the treatment burden–benefits ratio and to predict the response. The correlation between TNM staging and histology variations in a sample of patients who underwent neoadjuvant chemotherapy demonstrates a positive impact on both increasing conservative surgery and achieving pCR, resulting in better outcomes in terms of disease-free survival (DFS) and the risk of relapse. Benefits have also been highlighted in terms of cosmetic outcomes, postoperative complications, and psychological benefits. However, the overall outcomes must be evaluated according to the subtype and individual characteristics of the patients.
- Subjects
UNITED States; BREAST cancer prognosis; CLINICAL drug trials; STATISTICAL correlation; CONSERVATIVE treatment; BREAST tumors; PATHOLOGIC complete response; ANTINEOPLASTIC agents; TREATMENT effectiveness; IN vivo studies; CANCER chemotherapy; IMMUNOHISTOCHEMISTRY; SURGICAL complications; COMBINED modality therapy; RESEARCH; PROGRESSION-free survival; TUMOR classification; HEALTH care teams; OVERALL survival; HISTOLOGY
- Publication
Cancers, 2024, Vol 16, Issue 13, p2332
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16132332