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- Title
A Novel Rat Model to Simulate the Benign Esophageal Stricture Induced by Endoscopic Submucosal Dissection.
- Authors
Luo, Yin-Gen; Zhang, Xiao-Wu; Zhao, He; Li, Jin-Gui; Tsauo, Jiay-Wei; Gong, Tao; Ou, Ai-Xin; Cong, Tian-Hao; Kang, Wen-Di; Li, Xiao
- Abstract
This study aimed to establish a rat model that simulates benign esophageal strictures induced by endoscopic submucosal dissection (ESD). Materials and Methods: Sixteen male Sprague-Dawley rats were randomly divided into mucosal resection (n = 8) and sham-operated groups (n = 8). The rats in the mucosal resection group underwent a 5-mm three-fourths mucosal resection by way of a 3-mm incision in the distal esophagus under direct visualization via laparotomy. Rats in the sham-operated group underwent a 3-mm incision of the muscularis propria layer in the distal esophagus via laparotomy without mucosal resection. Dysphagia score, weight gain, mucosal constriction rate, and histology were evaluated 2 weeks after surgery. Results: Technical success was achieved in all the animals. One rat in the mucosal resection group died of infection, and no other complications were observed. Weight gain (P < 0.001) and luminal diameter derived from the esophagograms (P < 0.001) were significantly lower in the mucosal resection group than those in the sham-operated group. Dysphagia score (P < 0.001) and mucosal constriction rate (P < 0.001) were significantly higher in the mucosal resection group than those in the sham-operated group. The inflammation grade (P = 0.002), damage to the muscularis propria (P < 0.001), number of nascent microvessels (P = 0.006), and degree of α-SMA positive deposition (P = 0.006) were significantly higher in the mucosal resection group. Conclusion: A rat model of benign esophageal stricture induced by ESD was successfully and safely established by mucosal resection.
- Subjects
ANIMAL disease models; SPRAGUE Dawley rats; WEIGHT gain; DISSECTION; ESOPHAGEAL stenosis
- Publication
Clinical & Experimental Gastroenterology, 2024, Vol 17, p41
- ISSN
1178-7023
- Publication type
Article
- DOI
10.2147/CEG.S435690