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- Title
Hematological Alterations in Patients Recovered from SARS-CoV-2 Infection in Havana, Cuba.
- Authors
Pereira-Roche, Nayade; Roblejo-Balbuena, Hilda; Marín-Padrón, Lilia C.; Izaguirre-Rodríguez, Rodolfo; Sotomayor-Lugo, Francisco; Zúñiga-Rosales, Yaima; González-Torres, María de los Ángeles; Pérez-Rodríguez, Jacqueline; Álvarez-Gavilán, Yudelmis; Torres-Rives, Bárbara; Bravo-Ramírez, Maidalys; Benítez-Codero, Yudelkis; Monzón-Benítez, Giselle; Silva-Ayçaguer, Luis C.; Marcheco-Teruel, Beatriz
- Abstract
INTRODUCTION COVID-19 sequelae, or the short-, medium-, and long-term manifestations of the disease are under continuous study. There are currently few reports on the evolution of hematological variables following a demonstrated absence of SARS-CoV-2 after infection. OBJECTIVE Identify hematological alterations in Cuban adults recovered from SARS-CoV-2 infection, and their relation with disease severity. METHODS We selected 348 persons recovered from COVID-19 residing in Havana, Cuba with an RT-PCR study negative for SARS-CoV-2 performed two weeks after hospital discharge; a structured survey was administered to obtain clinical-epidemiological data. Three groups were established according to COVID-19 clinical criteria: asymptomatic, mild/ moderately symptomatic, and severely symptomatic, which, in turn, were divided according to hospital discharge date and blood sample collection date. We performed hemograms with differential leukocyte counts and compared results among groups. We then measured the associations between hematological variables, personal medical history, and relevant lifestyle habits (smoking). RESULTS All hematological variables were within normal reference limits, although men from the group of severely ill patients had increased total leukocytes, neutrophils and lymphocytes, and decreased hemoglobin and eosinophils, which was also evident in those with a recovery time of 31-90 days. CONCLUSIONS The relation between hematological variables and degree of clinical severity offers evidence as to persistence of systemic alterations (possibly inflammatory) associated with viral infection. Their identification and characterization can facilitate personalized patient followup and rehabilitation.
- Subjects
CUBA; REVERSE transcriptase polymerase chain reaction; LIFESTYLES; EOSINOPHILS; COVID-19; HEMOGLOBINS; CONVALESCENCE; SEVERITY of illness index; RISK assessment; COMPARATIVE studies; SEX distribution; NEUTROPHILS; BLOOD diseases; LEUKOCYTE count; BLOOD cell count; BLOOD testing; SMOKING; LYMPHOCYTE count; LEUCOCYTE disorders; DISEASE risk factors
- Publication
MEDICC Review, 2022, Vol 24, Issue 2, p7
- ISSN
1527-3172
- Publication type
Article
- DOI
10.37757/mr2022.v24.n2.1