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- Title
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia.
- Authors
Matsunaga, Takuya; Takemoto, Naofumi; Sato, Tsutomo; Takimoto, Rishu; Tanaka, Ikuta; Fujimi, Akihito; Akiyama, Takehide; Kuroda, Hiroyuki; Kawano, Yutaka; Kobune, Masayoshi; Kato, Junji; Hirayama, Yasuo; Sakamaki, Sumio; Kohda, Kyuhei; Miyake, Kensuke; Niitsu, Yoshiro
- Abstract
Cites that bone marrow minimal residual disease causes relapse after chemotherapy in patients with acute myelogenous leukemia. Inducement of the drug resistance by the attachment of very late antigen-4 (VLA-4) on leukemic cells; Resistance of VLA-4-positive cells to anoikis; Interaction between VLA-4 and fibronectin.
- Subjects
BONE marrow diseases; DISEASE relapse; DRUG therapy; ACUTE myeloid leukemia; PATIENTS
- Publication
Nature Medicine, 2003, Vol 9, Issue 9, p1158
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm909