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- Title
Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.
- Authors
Yao, T.‐C.; Tsai, H.‐J.; Tu, Y.‐L.; Chang, S.‐W.; Hua, M.‐C.; Liao, S.‐L.; Tsai, M.‐H.; Chiu, C.‐Y.; Lai, S.‐H.; Yeh, K.‐W.; Huang, J.‐L.
- Abstract
This study investigated the relationship between the specific immunoglobulin E ( Ig E) profile for 40 allergens using a novel microarray technique ( Bio IC) and fraction of exhaled nitric oxide ( Fe NO) in a population sample of 1321 children. Significant positive associations were found between Fe NO and sensitization to mites ( P < 0.001), animals ( P = 0.001), cockroaches ( P < 0.001), and foods ( P = 0.042), and furthermore, between Fe NO and the number of sensitizations (all P < 0.05) or the sum of specific Ig E (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher Fe NO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, Ig E sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated Fe NO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.
- Subjects
IMMUNOGLOBULIN E; SENSITIZATION (Neuropsychology); NITRIC oxide; CHILDREN'S health; ALLERGENS; DERMATOPHAGOIDES pteronyssinus
- Publication
Allergy, 2014, Vol 69, Issue 5, p678
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12378