OpenURL Connection Search

Select item for more details and to access through your institution.

In This Issue.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 489, doi. 10.1002/cpt.3377
Publication type:
Article
Highlighted Articles.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 497, doi. 10.1002/cpt.3376
Publication type:
Article
Getting the Dosage Right: A Vital Role for Clinical Pharmacology in the Era of Precision Medicine.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 491, doi. 10.1002/cpt.3375
By:
- Minichmayr, Iris K.;
- Shebley, Mohamad;
- van der Graaf, Piet H.;
- Venkatakrishnan, Karthik
Publication type:
Article
Dosage Optimization: A Regulatory Perspective for Developing Oncology Drugs.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 577, doi. 10.1002/cpt.3373
By:
- Rahman, Atiqur;
- Shah, Mirat;
- Shord, Stacy S.
Publication type:
Article
ASCPT News.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 499, doi. 10.1002/cpt.3372
Publication type:
Article
Population Pharmacokinetic and Exposure–Response Modeling to Inform Risankizumab Dose Selection in Patients With Ulcerative Colitis.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 847, doi. 10.1002/cpt.3330
By:
- Thakre, Neha;
- Goebel, Aline;
- Winzenborg, Insa;
- Suleiman, Ahmed A.;
- D'Cunha, Ronilda;
- Mensing, Sven;
- Liu, Wei;
- Pang, Yinuo
Publication type:
Article
Reply to: "Therapeutic Drug Monitoring of Oral Oncology Drugs: Another Example of Maslow's Hammer" and "Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails".
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 506, doi. 10.1002/cpt.3367
By:
- Combarel, David;
- Geraud, Arthur;
- Gougis, Paul
Publication type:
Article
Recent Advances Addressing the Challenges of Precision Dosing.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 527, doi. 10.1002/cpt.3365
By:
- Minichmayr, Iris K.;
- Mizuno, Tomoyuki;
- Goswami, Srijib;
- Peck, Richard W.;
- Polasek, Thomas M.
Publication type:
Article
Dosing Strategies and Quantitative Clinical Pharmacology for Bispecific T‐Cell Engagers Development in Oncology.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 637, doi. 10.1002/cpt.3361
By:
- Elmeliegy, Mohamed;
- Chen, Joseph;
- Dontabhaktuni, Aruna;
- Gaudy, Allison;
- Kapitanov, Georgi I.;
- Li, Junyi;
- Mim, Sabiha R.;
- Sharma, Sharad;
- Sun, Qin;
- Ait‐Oudhia, Sihem
Publication type:
Article
Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg‐Depleting Antibody.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 834, doi. 10.1002/cpt.3303
By:
- Belli, Sara;
- Amann, Maria;
- Hutchinson, Lucy;
- Pousse, Laurène;
- Abdolzade‐Bavil, Afsaneh;
- Justies, Nicole;
- Jacobsen, Bjoern;
- Ploix, Corinne;
- Tselempi, Eleni;
- Tosevski, Vinko;
- Koll, Hans;
- Schnetzler, Gabriel;
- Boetsch, Christophe;
- Marrer‐Berger, Estelle
Publication type:
Article
Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 504, doi. 10.1002/cpt.3368
By:
- Guchelaar, Niels A. D.;
- van der Kleij, Maud B. A.;
- Steeghs, Neeltje;
- Huitema, Alwin D. R.;
- Mathijssen, Ron H. J.;
- Koolen, Stijn L. W.
Publication type:
Article
Beyond MABEL: An Integrative Approach to First in Human Dose Selection of Immunomodulators by the Health and Environmental Sciences Institute (HESI) Immuno‐Safety Technical Committee (ITC).
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 546, doi. 10.1002/cpt.3316
By:
- Matsumoto, Mineo;
- Polli, Joseph Ryan;
- Swaminathan, Suresh K.;
- Datta, Kaushik;
- Kampershroer, Cris;
- Fortin, Marie C.;
- Salian‐Mehta, Smita;
- Dave, Rutwij;
- Yang, Zheng;
- Arora, Payal;
- Hiura, Masanori;
- Suzuki, Mizuho;
- Brennan, Frank R.;
- Sathish, Jean
Publication type:
Article
From Plan to Pivot: How Model‐Informed Drug Development Shaped the Dose Strategy of the Zibotentan/Dapagliflozin ZENITH Trials.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 653, doi. 10.1002/cpt.3362
By:
- Mercier, Anne‐Kristina;
- Ueckert, Sebastian;
- Sunnåker, Mikael;
- Hamrén, Bengt;
- Ambery, Phil;
- Greasley, Peter J.;
- Åstrand, Magnus
Publication type:
Article
Ticagrelor versus Adjusted‐Dose Prasugrel in Acute Coronary Syndrome with Percutaneous Coronary Intervention.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 747, doi. 10.1002/cpt.3209
By:
- Tsai, Ming‐Lung;
- Lin, Yuan;
- Chen, Dong‐Yi;
- Lin, Ming‐Shyan;
- Wang, Chao‐Yung;
- Hsieh, I‐Chang;
- Yang, Ning‐I;
- Hung, Ming‐Jui;
- Chen, Tien‐Hsing
Publication type:
Article
Dosing and Exposure of Vancomycin With Continuous Infusion: A Retrospective Study.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 665, doi. 10.1002/cpt.3221
By:
- Derijks‐Engwegen, Judith Y. M. N.;
- Jager, Nynke G.L.
Publication type:
Article
Getting the Dose Right: ASCPT Translational Precision Medicine (TPM) Network Perspectives.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 522, doi. 10.1002/cpt.3358
By:
- Ahmed, Mariam;
- Hassan, Hazem E.
Publication type:
Article
Extended Model‐Informed Drug Development: Beyond Clinical Trials and Regulatory Approval.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 518, doi. 10.1002/cpt.3357
By:
- Kamal, Mohamed A.;
- Ganguly, Samit;
- Kadambi, Ananth;
- Smith, Patrick F.
Publication type:
Article
Model‐Informed Reinforcement Learning for Enabling Precision Dosing Via Adaptive Dosing.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 619, doi. 10.1002/cpt.3356
By:
- Tosca, Elena Maria;
- De Carlo, Alessandro;
- Ronchi, Davide;
- Magni, Paolo
Publication type:
Article
Informing the Recommended Phase III Dose of Alnuctamab, a CD3 × BCMA T‐Cell Engager, Using Population Pharmacokinetics and Exposure–Response Analysis.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 866, doi. 10.1002/cpt.3353
By:
- Kiesel, Brian;
- Osawa, Mayu;
- Masilamani, Madhan;
- Bar, Merav;
- Hsu, Kevin;
- Godwin, Colin;
- Burgess, Michael;
- Lamba, Manisha;
- Gaudy, Allison
Publication type:
Article
Aging‐Related CYP3A Functional Changes in Chinese Older Patients: New Findings from Model‐Based Assessment of Amlodipine.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 858, doi. 10.1002/cpt.3347
By:
- Valerie Sia, Jie En;
- Lai, Xuan;
- Mak, Wen Yao;
- Wu, Xinyi;
- Zhang, Fan;
- Cui, Cheng;
- Liu, Dongyang;
- Xiang, Xiaoqiang
Publication type:
Article
Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 531, doi. 10.1002/cpt.3298
By:
- Samineni, Divya;
- Venkatakrishnan, Karthik;
- Othman, Ahmed A.;
- Pithavala, Yazdi K.;
- Poondru, Srinivasu;
- Patel, Chirag;
- Vaddady, Pavan;
- Ankrom, Wendy;
- Ramanujan, Saroja;
- Budha, Nageshwar;
- Wu, Michael;
- Haddish‐Berhane, Nahor;
- Fritsch, Holger;
- Hussain, Azher;
- Kanodia, Jitendra;
- Li, Meng;
- Li, Mengyao;
- Melhem, Murad;
- Parikh, Apurvasena;
- Upreti, Vijay V.
Publication type:
Article
Oral Drug Dosing After Gastric Bypass and Diet‐Induced Weight Loss: Simpler Than We Think? Lessons Learned From the COCKTAIL Study.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 647, doi. 10.1002/cpt.3307
By:
- Kvitne, Kine Eide;
- Hjelmesæth, Jøran;
- Hovd, Markus;
- Sandbu, Rune;
- Johnson, Line Kristin;
- Andersson, Shalini;
- Karlsson, Cecilia;
- Christensen, Hege;
- Jansson‐Löfmark, Rasmus;
- Åsberg, Anders;
- Robertsen, Ida
Publication type:
Article
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof‐of‐Concept Application of Liquid Biopsy in Renal Impairment.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 814, doi. 10.1002/cpt.3291
By:
- Rostami‐Hodjegan, Amin;
- Al‐Majdoub, Zubida M.;
- von Grabowiecki, Yannick;
- Yee, Ka Lai;
- Sahoo, Sudhakar;
- Breitwieser, Wolfgang;
- Galetin, Aleksandra;
- Gibson, Christopher;
- Achour, Brahim
Publication type:
Article
Model‐Informed Precision Dosing Using Machine Learning for Levothyroxine in General Practice: Development, Validation and Clinical Simulation Trial.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 824, doi. 10.1002/cpt.3293
By:
- Janssen Daalen, Jules M.;
- Doesburg, Djoeke;
- Hunik, Liesbeth;
- Kessel, Rogier;
- Herngreen, Thomas;
- Knol, Dennis;
- Ruys, Thony;
- van den Bemt, Bart J.F.;
- Schers, Henk J.
Publication type:
Article
Beyond Population‐Level Targets for Drug Concentrations: Precision Dosing Needs Individual‐Level Targets that Include Superior Biomarkers of Drug Responses.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 602, doi. 10.1002/cpt.3197
By:
- Polasek, Thomas M.;
- Peck, Richard W.
Publication type:
Article
Pharmacokinetics, Pharmacodynamics, and Safety of Edoxaban in Pediatric Subjects: A Phase I Single‐Dose Study.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 736, doi. 10.1002/cpt.3196
By:
- Zou, Peng;
- Zahir, Hamim;
- Duggal, Anil;
- Pandya, Grishma;
- Jin, James;
- Leil, Tarek A.
Publication type:
Article
A Score to Predict the Clinical Usefulness of Therapeutic Drug Monitoring: Application to Oral Molecular Targeted Therapies in Cancer.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 678, doi. 10.1002/cpt.3193
By:
- Géraud, Arthur;
- Combarel, David;
- Funck‐Brentano, Christian;
- Beaulieu, Quentin;
- Zahr, Noël;
- Broutin, Sophie;
- Spano, Jean‐Philippe;
- Massard, Christophe;
- Besse, Benjamin;
- Gougis, Paul
Publication type:
Article
Dose Optimization Informed by PBPK Modeling: State‐of‐the Art and Future.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 563, doi. 10.1002/cpt.3289
By:
- Rowland Yeo, Karen;
- Gil Berglund, Eva;
- Chen, Yuan
Publication type:
Article
Approval of Mycophenolate Mofetil for Prophylaxis of Organ Rejection in Pediatric Recipients of Heart or Liver Transplants: A Regulatory Perspective.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 807, doi. 10.1002/cpt.3288
By:
- Al‐Khouja, Amer;
- Chaudhri, Nadia;
- Velidedeoglu, Ergun;
- Belen, Ozlem;
- Bi, Youwei;
- Doddapaneni, Suresh;
- Chen, Jianmeng
Publication type:
Article
"Getting the Dose Right"—Revisiting the Topic With Focus on Biologic Agents.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 613, doi. 10.1002/cpt.3285
By:
- Mould, Diane R.;
- Upton, Richard N.
Publication type:
Article
From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 515, doi. 10.1002/cpt.3281
By:
- Morales Junior, Ronaldo;
- Amajor, Victor;
- Paice, Kelli;
- Kyler, Kathryn E.;
- Hambrick, H. Rhodes;
- Pavia, Kathryn E.;
- Haynes, Andrew S.;
- Gooden, Felicia;
- Pais, Gwendolyn M.;
- Downes, Kevin J.;
- Ramsey, Laura B.;
- Wagner, Jonathan;
- Tang Girdwood, Sonya
Publication type:
Article
Leveraging QSP Models for MIPD: A Case Study for Warfarin/INR.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 795, doi. 10.1002/cpt.3274
By:
- Falkenhagen, Undine;
- Cavallari, Larisa H.;
- Duarte, Julio D.;
- Kloft, Charlotte;
- Schmidt, Stephan;
- Huisinga, Wilhelm
Publication type:
Article
Transforming the Discovery of Targeted Protein Degraders: The Translational Power of Predictive PK/PD Modeling.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 770, doi. 10.1002/cpt.3273
By:
- Haid, Robin Thomas Ulrich;
- Reichel, Andreas
Publication type:
Article
Evaluation of Patient‐Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 782, doi. 10.1002/cpt.3272
By:
- Mandlekar, Sandhya;
- Sutaria, Dhruvitkumar S.;
- Yang, Xiaoyun;
- Johnson, Ryan;
- Zou, Yixuan;
- Dean, Brian;
- Chen, Liuxi;
- Sane, Rucha;
- Williams, Kathi;
- Cardenas, Alison;
- Simon, Mary;
- Fischer, Saloumeh
Publication type:
Article
Optimizing Dosage in Pharmacotherapy—Missing the Forest for the Trees.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 511, doi. 10.1002/cpt.3268
By:
- Abdel‐Rahman, Susan M.;
- Farrell, Andrew J.;
- Berry, N. Seth;
- Burckart, Gilbert J.
Publication type:
Article
Viral Kinetics Model of SARS‐CoV‐2 Infection Informs Drug Discovery, Clinical Dose, and Regimen Selection.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 757, doi. 10.1002/cpt.3267
By:
- Claas, Allison M.;
- Lee, Meelim;
- Huang, Pai‐Hsi;
- Knutson, Charles G.;
- Bullara, Domenico;
- Schoeberl, Birgit;
- Gaudet, Suzanne
Publication type:
Article
Therapeutic Drug Monitoring of Oral Oncology Drugs: Another Example of Maslow's Hammer.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 508, doi. 10.1002/cpt.3264
By:
- Ratain, Mark J.
Publication type:
Article
Model‐Informed Assessment of Probability of Phase 3 Success for Ritlecitinib in Patients with Moderate‐to‐Severe Ulcerative Colitis.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 724, doi. 10.1002/cpt.3251
By:
- Wojciechowski, Jessica;
- Mukherjee, Arnab;
- Banfield, Christopher;
- Nicholas, Timothy
Publication type:
Article
Assessment of Dosing Strategies for Pediatric Drug Products.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 716, doi. 10.1002/cpt.3250
By:
- Taylor, Zachary L.;
- Green, Francis G.;
- Hossain, Nayeem;
- Burckart, Gilbert J.;
- Pacanowski, Michael;
- Schuck, Robert N.
Publication type:
Article
Predicting the Long‐Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 703, doi. 10.1002/cpt.3246
By:
- Thorsted, Anders;
- Zecchin, Chiara;
- Berges, Alienor;
- Karlsson, Mats O.;
- Friberg, Lena E.
Publication type:
Article
Nonlinear Mixed‐Effects Model of Z‐Endoxifen Concentrations in Tamoxifen‐Treated Patients from the CEPAM Cohort.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 690, doi. 10.1002/cpt.3238
By:
- Mc Laughlin, Anna M.;
- Helland, Thomas;
- Klima, Fenja;
- Koolen, Stijn L.W.;
- van Schaik, Ron H.N.;
- Mathijssen, Ron H.J.;
- Neven, Patrick;
- Swen, Jesse J.;
- Guchelaar, Henk‐Jan;
- Dalenc, Florence;
- White‐Koning, Melanie;
- Michelet, Robin;
- Mikus, Gerd;
- Schroth, Werner;
- Mürdter, Thomas;
- Brauch, Hiltrud;
- Schwab, Matthias;
- Søiland, Håvard;
- Mellgren, Gunnar;
- Thomas, Fabienne
Publication type:
Article
Phenotypic Models of Drug–Drug‐Gene Interactions Mediated by Cytochrome Drug‐Metabolizing Enzymes.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 592, doi. 10.1002/cpt.3188
By:
- Viviani, Roberto;
- Berres, Judith;
- Stingl, Julia C.
Publication type:
Article
Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model‐Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 670, doi. 10.1002/cpt.3119
By:
- Power‐Hays, Alexandra;
- Dong, Min;
- Punt, Nieko;
- Mizuno, Tomoyuki;
- Smart, Luke R.;
- Vinks, Alexander A.;
- Ware, Russell E.
Publication type:
Article
Issue Information.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 479, doi. 10.1002/cpt.2946
Publication type:
Article

Found: 44