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- Title
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study.
- Authors
Satoshi Yokota; Yuji Takihara; Yoshihiro Takamura; Masaru Inatani; Yokota, Satoshi; Takihara, Yuji; Takamura, Yoshihiro; Inatani, Masaru
- Abstract
<bold>Background: </bold>To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography.<bold>Methods: </bold>Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups.<bold>Results: </bold>In the non-NVG group, the mean age was 66.2 ± 2.4 (mean ± standard error) years, mean maximum IOP was 18.8 ± 1.8 mmHg, mean cpRNFL thickness was 91.2 ± 3.9 μm, mean ALD was 407.0 ± 22.9 μm, and mean LT was 155.0 ± 4.7 μm. In the NVG group, the mean age was 61.4 ± 2.1 years, mean maximum IOP was 33.1 ± 1.6 mmHg, mean cpRNFL thickness was 73.6 ± 3.4 μm, mean ALD was 403.9 ± 20.1 μm, and mean LT was 156.9 ± 4.2 μm. The IOP was significantly higher and the cpRNFL was significantly thinner in the NVG group (P < 0.001 and P = 0.002, respectively). However, the age, ALD, and LT were not statistically different between the groups (P = 0.151, 0.919, and 0.757, respectively).<bold>Conclusions: </bold>Although the cpRNFL was thinner, the structure of the lamina cribrosa was unchanged in the NVG eyes. Axonal loss of the retinal ganglion cells in NVG patients was prior to lamina cribrosa deformation.
- Subjects
GLAUCOMA; OPTICAL coherence tomography; RETINAL diseases; DIABETIC retinopathy; INTRAOCULAR pressure; RETINAL ganglion cells; GLAUCOMA diagnosis; LONGITUDINAL method; NEURONS; OPTIC nerve; RETINA; VISUAL fields; CROSS-sectional method; RETROSPECTIVE studies; DISEASE complications; DIAGNOSIS
- Publication
BMC Ophthalmology, 2017, Vol 17, p1
- ISSN
1471-2415
- Publication type
journal article
- DOI
10.1186/s12886-017-0456-9