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- Title
Efficient synthesis of kainic acid analogues.
- Authors
Tamborini, Lucia; Mastronardi, Federica; Cullia, Gregorio; Ettari, Roberta; De Micheli, Carlo
- Abstract
The present paper deals with an improved synthesis of two molecular hybrids of AMPA and KA, compounds CIP-A and CIP-B, and their transformation into CIOP-A and CIOP-B, the corresponding amido derivatives. Exploiting the continuous-flow technology, a significant improvement in the synthesis of the glutamate agonists CIP-A and CIP-B was accomplished, in terms of overall yield, time, and excess of ethyl chlorooximinoacetate. Moreover, we find out the HPLC conditions suitable to separate, at a preparative level, the three intermediates formed in the 1,3-dipolar cycloaddition step.
- Subjects
KAINIC acid; CHEMICAL synthesis; CONTINUOUS flow reactors; EXCITATORY amino acid agonists; RING formation (Chemistry)
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2013, p377
- ISSN
1551-7004
- Publication type
Article