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- Title
BIOLOGICAL EFFECTS OF PROTON RADIATION: AN UPDATE.
- Authors
Girdhani, S.; Sachs, R.; Hlatky, L.
- Abstract
Proton radiation provides significant dosimetric advantages when compared with gamma radiation due to its superior energy deposition characteristics. Although the physical aspects of proton radiobiology are well understood, biological and clinical endpoints are understudied. The current practice to assume the relative biological effectiveness of low linear energy transfer (LET) protons to be a generic value of about 1.1 relative to photons likely obscures important unrecognised differentials in biological response between these radiation qualities. A deeper understanding of the biological properties induced by proton radiation would have both radiobiological and clinical impact. This article briefly points to some of the literature pertinent to the effects of protons on tissue-level processes that modify disease progression, such as angiogenesis, cell invasion and cancer metastasis. Recent findings hint that proton radiation may, in addition to offering improved radio-therapeutic targeting, be a means to provide a new dimension for increasing therapeutic benefits for patients by manipulating these tissue-level processes.
- Subjects
RADIATION doses; PHYSIOLOGICAL effects of radiation; PROTONS; LINEAR energy transfer; GAMMA rays
- Publication
Radiation Protection Dosimetry, 2015, Vol 166, p334
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncv178