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- Title
Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment.
- Authors
Amidi, Ali; Wu, Lisa M; Pedersen, Anders Degn; Mehlsen, Mimi; Pedersen, Christina Gundgaard; Rossen, Philip; Agerbæk, Mads; Zachariae, Robert
- Abstract
<bold>Purpose: </bold>The aim of the present study was to determine the prevalence of cognitive impairment (CI) in a group of testicular (TC) survivors by comparing their neuropsychological test scores with normative data and to assess their performance in specific cognitive domains.<bold>Methods: </bold>Seventy-two TC survivors were evaluated 2 to 7 years post-treatment with a neuropsychological test battery that assessed multiple cognitive domains-attention and working memory, processing speed, verbal fluency, learning and memory, and executive functioning. Test scores were compared with normative data, and CI status was calculated for each participant.<bold>Results: </bold>In group-level analyses, survivors exhibited significantly impaired scores on a majority (9/12) of the neuropsychological outcomes (p < 0.01). In individual-level analyses, 62.5 % of the survivors were classified as having CI, significantly exceeding the expected normative frequency of 25 % (binomial test: p < 0.001). In particular, CI was observed in multiple outcomes related to verbal learning and memory (29 to 33 % of participants), visual learning and memory (14-28 %), processing speed (8-24 %), executive functioning (17 %), and attention and working memory (4-15 %). No association was found between treatment modality (surgery ± chemotherapy) and CI.<bold>Conclusions: </bold>The prevalence of CI in TC survivors was unexpectedly high, with survivors performing significantly worse than expected on a majority of the neuropsychological outcomes. While the findings are preliminary in nature, they still have important implications for the diagnosis and treatment of CI in TC survivors.
- Subjects
COGNITION disorders diagnosis; COGNITION disorders; COMPARATIVE studies; GERM cell tumors; LONGITUDINAL method; NEUROPSYCHOLOGICAL tests; RESEARCH methodology; MEDICAL cooperation; QUALITY of life; RESEARCH; TESTIS tumors; EVALUATION research; DISEASE complications
- Publication
Supportive Care in Cancer, 2015, Vol 23, Issue 10, p2973
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-015-2663-3