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- Title
Safety, tolerability, and efficacy of oxaliplatin-based adjuvant chemotherapy after curative resection of hepatic or extrahepatic metastases of Stage IV colorectal cancer.
- Authors
Nakayama, Izuma; Suenaga, Mitsukuni; Wakatsuki, Takeru; Ichimura, Takashi; Ozaka, Masato; Takahari, Daisuke; Shinozaki, Eiji; Chin, Keisho; Ueno, Masashi; Mizunuma, Nobuyuki; Yamaguchi, Toshiharu
- Abstract
Purpose: Surgery is the only potentially curative strategy for patients who have Stage IV colorectal cancer (CRC) with resectable metastases, but relapse is common. Randomized trials of adjuvant 5-FU-based systemic chemotherapy have not demonstrated any benefit after resection of liver metastases. We evaluated the efficacy, safety, and tolerability of oxaliplatin-based adjuvant chemotherapy after curative resection of hepatic or extrahepatic metastases of CRC. Methods: We retrospectively studied data for 88 consecutive patients with Stage IV CRC who underwent curative resection of metastases followed by oxaliplatin-based adjuvant chemotherapy between March 2007 and June 2013. Results: The 3-year relapse-free survival (RFS) rate was 54.0 %. There was no significant difference in 3-year RFS between patients with metastases confined to the liver (52.7 %) and patients with extrahepatic metastases (57.2 %). Multivariate analysis revealed that the site of the primary tumor (right-sided colon or left-sided colon/rectum) and the number of metastases (solitary or multiple) were predictors of RFS. Scheduled courses were completed in 80.7 % of the patients. Except for neutropenia (47.7 %), severe adverse events were observed in <5 % of patients. Conclusions: Oxaliplatin-based adjuvant chemotherapy could be an effective option for selected patients with Stage IV CRC after curative resection of hepatic or extrahepatic metastases, and is both safe and tolerable.
- Subjects
COLON cancer treatment; DRUG tolerance; MEDICATION safety; DRUG efficacy; OXALIPLATIN; CANCER chemotherapy; SURGICAL excision; THERAPEUTICS
- Publication
Cancer Chemotherapy & Pharmacology, 2015, Vol 76, Issue 1, p133
- ISSN
0344-5704
- Publication type
Article
- DOI
10.1007/s00280-015-2780-1