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- Title
Accumulation of Fascin+ cells during experimental autoimmune neuritis.
- Authors
Zichen Yang; Jian Sun; Xiaofeng Yang; Zhiyuan Zhang; Bangwei Lou; Jian Xiong; Schluesener, Hermann J.; Zhiren Zhang
- Abstract
Background Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles. Methods Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats. Results A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN, Conclusion Our results suggest a pathological role of Fascin in EAN.
- Subjects
AUTOIMMUNE diseases; NEURITIS; POLYNEUROPATHIES; DEMYELINATION; NERVOUS system; IMMUNOHISTOCHEMISTRY; LABORATORY rats
- Publication
Diagnostic Pathology, 2013, Vol 8, Issue 1, p1
- ISSN
1746-1596
- Publication type
Article
- DOI
10.1186/1746-1596-8-213