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- Title
Parathyroidectomy After Kidney Transplantation: A Single-Center Experience.
- Authors
Parmaksız, Ergün; Meşe, Meral; Yalın, Serkan Feyyaz; Haras, Ali Burak; Akyüz, Okan; Bahçebaş, Zerrin Bicik
- Abstract
Objective: Even after successful kidney transplantation, 10% to 50% of kidney transplant recipients have persistent hyperparathyroidism. Parathyroidectomy (PTX) has been reported to be associated with deterioration of renal function and reduced graft survival. The aim of this single-center, retrospective study was to analyze the long-term effect of PTX on calcium, phosphorus, and parathyroid hormone (PTH) levels, as well as the estimated glomerular filtration rate (eGFR), in renal transplantation patients who underwent PTX. Methods: The study population consisted of 154 patients followed between January 2014 and December 2017, 9 of whom underwent PTX. The median PTH, calcium, phosphorus, and eGFR values were recorded before and after PTX. Results: The median preparathyroidectomy PTH, calcium, phosphorus, and eGFR values were 311.57 pg/mL, 11.02 mg/dL, 2.35 mg/dL, and 90.88 mL/minute, respectively. When compared with the baseline figures, there was a decrease in PTH (311.5 vs. 147.5 pg/mL; p=0.015), calcium (11.02 vs. 9.01 mg/dL; p=0.017), and eGFR (90.88 vs. 75.44 mL/minute; p=0.008), and an increase in the phosphorus level (2.35 vs. 3.4 mg/dL; p=0.06) 1 month after surgery. The eGFR returned to the baseline rate 1 year after surgery (90.88 vs. 79.39 mL/minute; p=0.11). Conclusion: PTX in renal transplant recipients appears to be a safe procedure. Although renal function deteriorates in the acute period following PTX, long-term stabilization occurs.
- Subjects
PARATHYROIDECTOMY; KIDNEY transplantation; HYPERPARATHYROIDISM; GLOMERULAR filtration rate; PARATHYROID hormone
- Publication
Southern Clinics of Istanbul Eurasia, 2018, Vol 29, Issue 3, p194
- ISSN
2587-0998
- Publication type
Article
- DOI
10.14744/scie.2018.02996