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- Title
The Role of MicroRNA and LncRNA-MicroRNA Interactions in Regulating Ischemic Heart Disease.
- Authors
Na Li; Ponnusamy, Murugavel; Meng-peng Li; Kun Wang; Pei-Feng Li; Li, Na; Li, Meng-Peng; Wang, Kun; Li, Pei-Feng
- Abstract
Approximately 2% of the human genome consists of protein-coding regions. Therefore, the majority of transcripts are noncoding RNAs, such as microRNA (miRNA) and long noncoding RNAs (lncRNAs). In ischemic heart disease, the majority of miRNAs are repressors or destabilizers of target messenger RNAs. The lncRNAs are a second class of noncoding RNAs that have recently gained attention for their roles in heart disease and in regulating the functions of miRNA. In this review, we summarize the role of miRNA in pathological cardiac hypertrophy and myocardial infarction. In addition, we discuss the functional interactions of miRNA and lncRNA and its impact on these ischemic heart diseases.
- Subjects
CORONARY disease; CORONARY heart disease treatment; MICRORNA; GENETICS
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2017, Vol 22, Issue 2, p105
- ISSN
1074-2484
- Publication type
journal article
- DOI
10.1177/1074248416667600