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- Title
Lanthanum Carbonate Delays Progression of Coronary Artery Calcification Compared With Calcium-Based Phosphate Binders in Patients on Hemodialysis: A Pilot Study.
- Authors
Ohtake, Takayasu; Kobayashi, Shuzo; Oka, Machiko; Furuya, Rei; Iwagami, Masao; Tsutsumi, Daimu; Mochida, Yasuhiro; Maesato, Kyoko; Ishioka, Kunihiro; Moriya, Hidekazu; Hidaka, Sumi
- Abstract
Background and Objectives: Coronary artery calcification (CAC) is associated with future cardiovascular events and/or deathof patients on hemodialysis (HD). We investigated whether progression of CAC in patients on HD could be delayed by switchingfrom a calcium (Ca)-based phosphate (Pi) binder to lanthanum carbonate. Design, Setting, Participants, and Measurements:The CAC scores were evaluated at study enrollment and after 6 months in 52 patients on HD using calcium carbonate (CC) as a Pibinder. Patients were randomly divided into 2 groups assigned to receive either CC or lanthanum carbonate (LC), and the CACscores were evaluated after a 6-month treatment period. Progression of CAC was assessed, as were serum levels of Ca, Pi, andintact parathyroid hormone (iPTH). Results: Forty-two patients completed the study (23 receiving CC and 19 receiving LC). Inthe 6 months prior to randomization, all patients were treated with CC. During this 6-month period, the CAC scores increasedsignificantly in all 42 patients. Once randomized, there was significantly less progression in the group treated with LC than withCC. Changes in CAC scores from 6 to 12 months were significantly smaller in the LC group than the CC group (-288.9±1176.4vs 107.1±559.6, P = .036), and percentage changes were also significantly different (-6.4% vs 41.2%, P = .024). Serum Ca, Pi, andiPTH levels were similar in both groups during the study period. Conclusions: This pilot study suggested that LC delayedprogression of CAC in patients on HD compared with CC.
- Subjects
CORONARY disease; CARDIOVASCULAR diseases; PHYSIOLOGICAL effects of calcium; PARATHYROID hormone; LANTHANUM compounds
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2013, Vol 18, Issue 5, p439
- ISSN
1074-2484
- Publication type
Article
- DOI
10.1177/1074248413486355