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- Title
Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation: A Multicenter Prospective Observational Study.
- Authors
Hatakeyama, Junji; Inoue, Shigeaki; Liu, Keibun; Yamakawa, Kazuma; Nishida, Takeshi; Ohshimo, Shinichiro; Hashimoto, Satoru; Kanda, Naoki; Maruyama, Shuhei; Ogata, Yoshitaka; Kawakami, Daisuke; Shimizu, Hiroaki; Hayakawa, Katsura; Tanaka, Aiko; Oshima, Taku; Fuchigami, Tatsuya; Yawata, Hironori; Oe, Kyoji; Kawauchi, Akira; Yamagata, Hidehiro
- Abstract
Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge. Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis. Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1–4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05–1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey. Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
- Subjects
COVID-19; ARTIFICIAL respiration; FACTOR analysis; LONGITUDINAL method; RISK assessment
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 19, p5758
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11195758