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- Title
Gut Microbiome Modification through Dietary Intervention in Patients with Colorectal Cancer: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial in Patients with Scheduled Surgical Intervention for CRC.
- Authors
Martínez-Sánchez, María Antonia; Núñez-Sánchez, María Ángeles; Balaguer-Román, Andrés; Oliva-Bolarín, Alba; Pujante-Gilabert, Gabriel; Hernández-Agüera, Quiteria; Mesa-López, María José; Egea-Valenzuela, Juan; Queipo-Ortuño, María Isabel; Ruiz-Alcaraz, Antonio José; Ferrer-Gómez, Mercedes; Gil-Martínez, José; Ramos-Molina, Bruno
- Abstract
Colorectal cancer (CRC) is the third most common cancer and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable and environmental factors, which are the latest to be closely associated with nutritional habits, physical activity, obesity, and the gut microbiota. The latter may also play a key role in CRC prognosis and derived complications in patients undergoing surgery. This is a single-center, open, controlled, randomized clinical trial, in patients with scheduled surgical intervention for CRC. The primary objective is to assess whether a pre-surgical nutritional intervention, based on a high-fiber diet rich in polyunsaturated fatty acids (PUFAs), can reduce disturbances of the gut microbiota composition and, consequently, the rate of post-surgical complications in patients with CRC. Patients will be randomized in a 1:1 ratio after receiving a diagnosis of CRC. In the control arm, patients will receive standard nutritional recommendations, while patients in the intervention arm will be advised to follow a high-fiber diet rich in PUFAs before surgery. Participants will be followed up for one year to evaluate the overall rate of postsurgical complications, recurrences of CRC, response to adjuvant therapy, and overall/disease-free survival.
- Subjects
GUT microbiome; COLORECTAL cancer; CANCER patients; HIGH-fiber diet; CLINICAL trials; FECAL microbiota transplantation; SIGMOIDOSCOPY
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 13, p3613
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11133613