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- Title
Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study.
- Authors
Zha, Ling; Sobue, Tomotaka; Takeuchi, Taro; Tanaka, Kenta; Katayama, Yusuke; Komukai, Sho; Hirayama, Atsushi; Shimazu, Takeshi; Kitamura, Tetsuhisa
- Abstract
The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the ICU between February and November 2020, in Osaka Prefecture, Japan. A Cox proportional hazards model was used to assess the association between epidemiological factors and mortality among ICU patients. Of the 205 ICU patients, 161 (78.5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had comorbidities. The most common symptoms at diagnosis were mild (n = 131, 63.9%). A total of 187 patients (91.2%) received mechanical ventilation, and 32 patients (15.6%) required extracorporeal membrane oxygenation. Patients were followed up for a median of 25 days after ICU admission. A total of 147 patients (71.7%) were alive at discharge, and 58 patients (28.3%) died. The hazard ratio for mortality among patients aged >80 years was 6.02 (95% confidence interval: 2.10−17.25) in the multivariable model, which was higher than that among those aged ≤59 years. These results are useful for recognizing the clinical course of this infection in ICU patients.
- Subjects
JAPAN; OSAKA (Japan); COVID-19; INTENSIVE care patients; PROPORTIONAL hazards models; EXTRACORPOREAL membrane oxygenation; INTENSIVE care units
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 11, p2477
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10112477