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- Title
Persistence with Anticoagulation for Atrial Fibrillation: Report from the GLORIA-AF Phase III 1-Year Follow-up.
- Authors
Kozieł, Monika; Mazurek, Michał; Teutsch, Christine; Diener, Hans-Christoph; Dubner, Sergio J.; Halperin, Jonathan L.; Ma, Chang-Sheng; Rothman, Kenneth J.; Brandes, Axel; Paquette, Miney; Zint, Kristina; França, Lionel Riou; Lu, Shihai; Bartels, Dorothee B.; Huisman, Menno V.; Lip, Gregory Y. H.
- Abstract
Background: We aimed to assess the extent to which drug persistence is better with non-vitamin K antagonist oral anticoagulants (NOACs) than vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients and to estimate the difference in therapy persistence depending on NOAC dosing regimen (once daily (QD) vs. twice daily (BID)). Methods: Consecutive patients were followed for 1 year in phase III of the GLORIA-AF registry. Drug persistence was defined as the use of OAC without any discontinuation in >30 days or switching to alternative therapy. Results: Among 21,109 eligible patients in phase III, 17,266 patients who were prescribed OAC at baseline and those who took ≥1 OAC dose were included. The 1-year proportion of patients receiving NOAC and VKA who persisted on treatment was 80% and 75%, respectively. The 1-year persistence with NOACs BID and NOACs QD was 81% and 80%, respectively. Female gender, hypertension, older age, alcohol use, permanent, asymptomatic, and minimally symptomatic AF were associated with better OAC persistence. Region, medication usage predisposing to bleeding, being a current smoker, treatment reimbursement, and proton pump inhibitors were associated with lower OAC persistence. Conclusions: Drug persistence was higher with NOACs (1-year persistence was 80%) than with VKAs (75%). There was little difference in 1-year persistence between NOAC dosing regimens.
- Subjects
ATRIAL fibrillation; ANTICOAGULANTS; PROTON pump inhibitors; ALCOHOL drinking
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 6, p1969
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9061969