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- Title
Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy: A Systematic Review and Meta-analysis.
- Authors
Watanabe, Atsuyuki; Yasuhara, Jun; Iwagami, Masao; Miyamoto, Yoshihisa; Yamada, Yuji; Suzuki, Yukio; Takagi, Hisato; Kuno, Toshiki
- Abstract
This study evaluates the association between COVID-19 vaccination during pregnancy and peripartum outcomes. Key Points: Question: Is COVID-19 vaccination during pregnancy associated with increased risks of peripartum adverse outcomes? Findings: In this systematic review and meta-analysis, COVID-19 vaccination during pregnancy was not associated with increased risks of peripartum adverse outcomes, including preterm birth, small size for gestational age, low Apgar score at 5 minutes, cesarean delivery, postpartum hemorrhage, and chorioamnionitis. Furthermore, COVID-19 vaccination during pregnancy was associated with lower risks of neonatal intensive care unit admission, intrauterine fetal death, and maternal SARS-CoV-2 infection. Meaning: In this study, COVID-19 vaccination appeared to be safe and beneficial to pregnant individuals. Importance: The risk and benefits of COVID-19 vaccination during pregnancy are under investigation. Pooled evidence regarding neonatal and maternal outcomes in association with COVID-19 vaccination during pregnancy is scarce. Objective: To evaluate the association between COVID-19 vaccination during pregnancy and peripartum outcomes. Data Sources: PubMed and EMBASE databases were searched on April 5, 2022. Language restrictions were not applied. Study Selection: Prospective trials and observational studies comparing the individuals who received at least 1 COVID-19 vaccination during pregnancy with those who did not and reporting the neonatal outcomes, including preterm birth, small for gestational age, low Apgar score, neonatal intensive care units (NICU) admission, and intrauterine fetal death (IFD). Data Extraction and Synthesis: Two independent investigators extracted relevant data from each study. Odds ratios (ORs) were calculated using a random-effects model. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Main Outcomes and Measures: The primary outcomes were the neonatal outcomes, including preterm birth, small for gestational age, low Apgar score, NICU admission, and IFD. The secondary outcomes were maternal outcomes, including maternal SARS-CoV-2 infection, cesarean delivery, postpartum hemorrhage, and chorioamnionitis. Results: Nine observational studies involving 81 349 vaccinated (mean age, 32-35 years) and 255 346 unvaccinated individuals during pregnancy (mean age, 29.5-33 years) were included. COVID-19 vaccination during pregnancy was associated with lower risk of NICU admission (OR, 0.88; 95% CI, 0.80-0.97) and IFD (OR, 0.73; 95% CI, 0.57-0.94), whereas there was no statistically significant association with preterm birth (OR, 0.89; 95% CI, 0.76-1.04), small for gestational age (OR, 0.99; 95% CI, 0.94-1.04), and low Apgar score (OR, 0.94; 95% CI, 0.87-1.02). COVID-19 vaccination during pregnancy was associated with a lower risk of maternal SARS-CoV-2 infection (OR, 0.46; 95% CI, 0.22-0.93), whereas it was not associated with increased risk of cesarean delivery (OR, 1.05; 95% CI, 0.93-1.20), postpartum hemorrhage (OR, 0.95; 95% CI, 0.83-1.07), and chorioamnionitis (OR, 1.06; 95% CI, 0.86-1.31). Conclusions and Relevance: COVID-19 vaccination during pregnancy was not associated with an increase in the risk of peripartum outcomes, was associated with a decreased risk of NICU admission, IFD, and maternal SARS-CoV-2 infection. Thus, COVID-19 vaccination should be encouraged for pregnant individuals.
- Subjects
ONLINE information services; META-analysis; MEDICAL information storage &; retrieval systems; NEONATAL intensive care; COVID-19; CONFIDENCE intervals; POSTPARTUM hemorrhage; COVID-19 vaccines; SYSTEMATIC reviews; NEONATAL intensive care units; PREGNANCY outcomes; FETAL diseases; DESCRIPTIVE statistics; MEDLINE; ODDS ratio; CESAREAN section; PERINATAL period
- Publication
JAMA Pediatrics, 2022, Vol 176, Issue 11, p1098
- ISSN
2168-6203
- Publication type
Article
- DOI
10.1001/jamapediatrics.2022.3456