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- Title
Clinical application and development of tumor biomarkers.
- Authors
Hsing-Yu Chen; Tai-Yin Wu; Chi-Fen Cheng; Kuan-Liang Kuo; Chien-Chih Chen
- Abstract
Periodic health examinations are common practice in Taiwan. Tumor markers are popular laboratory tests which are ordered as part of a health check-up; however, the significance of tumor markers is only partially understood by people. The purpose of this article was to report recent clinical developments and applications of tumor markers. We searched and studied relevant review articles about tumor markers published in the 10 years between 2003 and 2013. We present the definition, classification, characteristics, and clinical roles of tumor markers corresponding to lung, hepatic, colorectal, breast, prostatic, pancreatic, and ovarian cancers. We also report newly developed tumor markers. Although novel tumor markers have flourished in the recent 10-20 years, novel tumor markers cannot replace the well-established tumor markers, such as α-fetoprotein and cancer antigen 125. Studies focusing on the application of novel tumor markers in early disease detection and diagnosis are limited. There is still a need for close collaboration between bench and bedside to search for more widely applicable markers and to improve cancer prevention. Thus, public health workers should exercise caution in explaining the meaning of these tumor markers and avoid over-interpretation or over-reliance on novel tumor markers.
- Publication
Taiwan Journal of Publich Health / Taiwan Gong Gong Wei Sheng Za Zhi, 2014, Vol 33, Issue 4, p352
- ISSN
1023-2141
- Publication type
Article
- DOI
10.6288/TJPH201433103030