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- Title
Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours.
- Authors
Kadyrov, Maria; Whiley, Luke; Brown, Belinda; Erickson, Kirk I.; Holmes, Elaine
- Abstract
One of the most recognisable features of ageing is a decline in brain health and cognitive dysfunction, which is associated with perturbations to regular lipid homeostasis. Although ageing is the largest risk factor for several neurodegenerative diseases such as dementia, a loss in cognitive function is commonly observed in adults over the age of 65. Despite the prevalence of normal age-related cognitive decline, there is a lack of effective methods to improve the health of the ageing brain. In light of this, exercise has shown promise for positively influencing neurocognitive health and associated lipid profiles. This review summarises age-related changes in several lipid classes that are found in the brain, including fatty acyls, glycerolipids, phospholipids, sphingolipids and sterols, and explores the consequences of age-associated pathological cognitive decline on these lipid classes. Evidence of the positive effects of exercise on the affected lipid profiles are also discussed to highlight the potential for exercise to be used therapeutically to mitigate age-related changes to lipid metabolism and prevent cognitive decline in later life.
- Subjects
COGNITION disorders; NUCLEAR magnetic resonance spectroscopy; LIPID metabolism
- Publication
Metabolites (2218-1989), 2022, Vol 12, Issue 9, p822
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo12090822