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- Title
In silico Analysis of Candida albicans Phosphomannose Isomerase as a Drug Target: Identification of Lead Compounds in a Polyherbal Formulation.
- Authors
Vidyadharan, Pravi; Nair, Lekshmysree S.; Aswathy, S.; Umesh, P.; Nair, Achuthsankar S.; Sudhakaran, P. R.
- Abstract
The fungal cell wall which consists of several molecular components that are either absent or different from mammalian cells is a potent target for antifungal agents. Mannose linked glycoconjugates constitute an important set of molecular components of the cell wall critical for survival and virulence of Candida albicans (C. albicans), which is the most common causative agent of human fungal infections. The present work explores the antifungal potential of poly herbal preparations against phospho-mannose isomerase, a key enzyme catalyzing the formation of mannose precursors in the biosynthesis of cell wall glycoconjugates of C. albicans. For this, preliminary screening of five Ayurvedic formulations was performed by disc diffusion method. Further, in silico docking studies were performed using the phytochemicals of potent preparation so as to identify the active component. The study indicated that from among the compounds present in herbs used in the formulation, Gilloin exhibited the best interacting features against Candida PMI over human PMI and revealed the possibility of considering PMI as an antifungal target particularly in formulations for external applications.
- Subjects
CANDIDA albicans; PHOSPHOMANNAN; ANTIFUNGAL agents
- Publication
Trends in Carbohydrate Research, 2016, Vol 8, Issue 1, p36
- ISSN
0975-0304
- Publication type
Article