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- Title
Expression of leucocyte function--associated antigen--1 and 7F7--antigen, an adhesion molecule related to intercellular adhesion molecule--1 (ICAM--1) in non--Hodgkin lymphomas and leukaemias: possible influence on growth pattern and leukaemic behaviour.
- Authors
Stauder, R.; Greil, R.; Schulz, T. F.; Thaler, J.; Gattringer, C.; Radaskiewicz, T.; Dierich, M. P.; Huber, H.
- Abstract
In 160 non-Hodgkin lymphomas (NHL) of B and T cell origin the expression of leucocyte function- associated antigen-i (LFA-1) and one of its counter-structures named 7F7-antigen was studied. Functional and structural similarities and the 7F7-reactivity of pICAM-1 transfected COS-cells prove that 7F7-antigen is identical with ICAM-1. The expression of both adhesion structures occurred variably and clearly depended on the maturation stage and on the B and T cell origin of lymphomas but was not associated with the proliferative status of tumour cells. The concomitant expression of both adhesion molecules was a characteristic feature of germinal centre derived NHL, particularly of those with neoplastic follicular structures (corr. contingency coeff. = 0506; P<0.02), whereas both adhesion structures were less often expressed on lymphomas with a more diffuse pattern of tumour infiltration. Most B-NHL of low-grade malignancy expressed LFA-1 while their counterparts of high-grade malignancy often tended to be LFA-1 negative. In B cell neoplasias of low-grade malignancy the lack of ICAM-1 and a leukaemic course of the disease were significantly correlated (P<0.0005). The results indicate that the differential expression of both adhesion molecules may account for distinct patterns of growth and spread in subtypes of lymphoid malignancies.
- Subjects
LYMPHOCYTES; HODGKIN'S disease; LYMPHOPROLIFERATIVE disorders; LYMPH nodes; B cells; CANCER cells
- Publication
Clinical & Experimental Immunology, 1989, Vol 77, Issue 2, p234
- ISSN
0009-9104
- Publication type
Article