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- Title
Recent Strategies for the Immobilization of Therapeutic Enzymes.
- Authors
Zhu, Chen-Yuan; Li, Fei-Long; Zhang, Ye-Wang; Gupta, Rahul K.; Patel, Sanjay K. S.; Lee, Jung-Kul
- Abstract
Therapeutic enzymes play important roles in modern medicine due to their high affinity and specificity. However, it is very expensive to use them in clinical medicine because of their low stability and bioavailability. To improve the stability and effectiveness of therapeutic enzymes, immobilization techniques have been employed to enhance the applications of therapeutic enzymes in the past few years. Reported immobilization techniques include entrapment, adsorption, and covalent attachment. In addition, protein engineering is often used to improve enzyme properties; however, all methods present certain advantages and limitations. For carrier-bound immobilization, the delivery and release of the immobilized enzyme depend on the properties of the carrier and enzyme. In this review, we summarize the advantages and challenges of the current strategies developed to deliver therapeutic enzymes and provide a future perspective on the immobilization technologies used for therapeutic enzyme delivery.
- Subjects
THERAPEUTIC immobilization; IMMOBILIZED enzymes; ENZYMES; PROTEIN engineering; CLINICAL medicine
- Publication
Polymers (20734360), 2022, Vol 14, Issue 7, p1409
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym14071409