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- Title
Genotype and phenotype correlation in intracranial hemorrhage in neonatal factor VII deficiency among Thai children.
- Authors
Traivaree, Chanchai; Monsereenusorn, Chalinee; Meekaewkunchorn, Arunotai; Laoyookhong, Premsak; Suwansingh, Saranya; Boonyawat, Boonchai
- Abstract
Congenital factor VII (FVII) deficiency is a rare inherited coagulopathy. The clinical manifestations and clinical findings vary widely, ranging from asymptomatic to life-threatening bleeding, including intracranial hemorrhage (ICH), with prolonged prothrombin time, normal partial thromboplastin time and normal platelet counts, which are confirmed by the low level of FVII assay. Treatment consists of fresh frozen plasma (FFP), prothrombin complex concentrates (PCCs), and recombinant activated FVII to treat bleeding and prophylactic therapy. Here, we report four patients with FVII levels <5% (severe type) who presented ICH during the neonatal period. The IVS6+1G>T was the most common (50%) mutation identified in our study, followed by the K376X nonsense mutation (37.5%). In our study, we found that genetic information affected the severity of congenital FVII deficiency with ICH.
- Subjects
GENOTYPES; PHENOTYPES; INTRACRANIAL hematoma; THAI people; PROTHROMBIN; DISEASES
- Publication
Application of Clinical Genetics, 2017, Vol 10, p37
- ISSN
1178-704X
- Publication type
Article
- DOI
10.2147/TACG.S139788