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- Title
Serum vascular endothelial growth factor (VEGF) and VEGF-C levels as tumor markers in patients with cervical carcinoma.
- Authors
Akira Mitsuhashi; Kiyomi Suzuka; Koji Yamazawa; Hideo Matsui; Katsuyoshi Seki; Souei Sekiya
- Abstract
Vascular endothelial growth factor (VEGF) and VEGF-C play a crucial role in the regulation of tumor growth and metastasis. The current study examined the significance of serum VEGF and VEGF-C levels in relation to conventional clinicopathologic parameters, response to treatment, and survival in patients with cervical carcinoma.Between December 1999 and March 2004, serum VEGF and VEGF-C levels were analyzed in 78 patients with cervical carcinoma undergoing primary treatment (primary surgery [n = 40] and radiotherapy [n = 38]), as well as in 30 healthy controls. Serum VEGF and VEGF-C levels were assessed by enzyme-linked immunosorbent assay before and within 2 weeks after treatment.Serum VEGF and VEGF-C levels were higher in patients with cervical carcinoma than in the healthy control (P = 0.0002 and P = 0.0007, respectively). Both VEGF and VEGF-C concentrations increased significantly in patients with squamous cell carcinoma (SCC vs. normal control: P < 0.0001 and P = 0.0001, respectively), but not in adenocarcinoma (vs. normal control: P = 0.2982 and P = 0.7766, respectively). In an analysis of SCC, the pretherapeutic serum levels of VEGF and VEGF-C correlated significantly with advanced International Federation of Gynecology and Obstetrics stage and large tumor size, but not with lymph node metastasis. The pretherapeutic serum level of VEGF-C also correlated significantly with disease recurrence or persistence after treatment. Both serum VEGF and VEGF-C levels decreased significantly after treatment.The serum levels of both VEGF and VEGF-C have potential usefulness as biologic markers of SCC of the uterine cervix. Cancer 2005. 2005 American Cancer Society.
- Subjects
VASCULAR endothelial growth factors; TUMOR growth; METASTASIS; CERVICAL cancer; RADIOTHERAPY; SQUAMOUS cell carcinoma
- Publication
Cancer (0008543X), 2005, Vol 103, Issue 4, p724
- ISSN
0008-543X
- Publication type
Article