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- Title
Evaluating the effect of immune cells on the outcome of patients with mesothelioma.
- Authors
Chee, Serena J; Lopez, Maria; Mellows, Toby; Gankande, Sharmali; Moutasim, Karwan A; Harris, Scott; Clarke, James; Vijayanand, Pandurangan; Thomas, Gareth J; Ottensmeier, Christian H
- Abstract
<bold>Background: </bold>We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma.<bold>Methods: </bold>A tissue microarray from 302 samples was constructed. Markers of adaptive immune response in T-cells (CD8+, FOXP3+, CD4+, CD45RO+, CD3+) and B-cells (CD20+), and of innate immune response; neutrophils (NP57+), natural killer cells (CD56+) and macrophages (CD68+) were evaluated.<bold>Results: </bold>We found that in the epithelioid tumours, high CD4+ and CD20+ counts, and low FOXP3+, CD68+ and NP57+ counts linked to better outcome. In the non-epithelioid group low CD8+ and low FOXP3+ counts were beneficial.On multivariate analysis low FOXP3+ remained independently associated with survival in both groups. In the epithelioid group additionally high CD4+, high CD20+, and low NP57+ counts were prognostic.<bold>Conclusions: </bold>Our data demonstrate for the first time, in predominately advanced disease, the association of key markers of adaptive and innate immunity with survival and the differential effect of histology. A better understanding of the immunological drivers of the different subtypes of mesothelioma will assist prognostication and disease-specific clinical decision-making.
- Subjects
B cells; CELL physiology; COMPARATIVE studies; KILLER cells; LONGITUDINAL method; LYMPHOCYTES; RESEARCH methodology; MEDICAL cooperation; MESOTHELIOMA; PROGNOSIS; RESEARCH; SURVIVAL; TUMOR classification; EVALUATION research
- Publication
British Journal of Cancer, 2017, Vol 117, Issue 9, p1341
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2017.269