We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Different contribution of substrates oxidation to insulin resistance in malnourished elderly patients with cancer.
- Authors
Gambardella, Antonio; Paolisso, Giuseppe; D'Amore, Anna; Granato, Marina; Verza, Mario; Varricchio, Michele; Gambardella, A; Paolisso, G; D'Amore, A; Granato, M; Verza, M; Varricchio, M
- Abstract
<bold>Background: </bold>The relative contribution of malnutrition and cancer to insulin resistance in elderly patients is still poorly understood.<bold>Methods: </bold>Twenty malnourished and 15 well-nourished patients with cancer matched for age (70 +/- 0.3 versus 69 +/- 0.3 years; P = not significant), mean arterial blood pressure (104 +/- 8 versus 107 +/- 7 mm Hg; P = not significant), gender ratio (10 males/10 females versus 7 males/8 females), and sedentary life style underwent an euglycemic glucose clamp. Simultaneous infusion of 3-D-H-glucose and indirect calorimetry allowed the authors to determine glucose turnover parameters and analyze substrates oxidation.<bold>Results: </bold>Malnourished patients displayed a reduced total body glucose metabolism (36 +/- 2 versus 31 +/- 3 mumol/kg of lean body mass x min P < 0.04) despite higher glucose oxidation. In the same group of patients, the authors demonstrated a significant increase in lipid oxidation and the lack of the inverse relationship between glucose and lipid oxidation (r = 0.07; P = not significant). Insulin infusion enhanced glucose oxidation and suppressed lipid oxidation, but such changes were at lower extent in malnourished patients.<bold>Conclusions: </bold>Our study confirms the presence of insulin resistance in malnourished patients and demonstrates the relative contribution of substrates oxidation to the insulin resistance itself.
- Subjects
GLUCOSE metabolism; PROTEIN metabolism; ENERGY metabolism; NUTRITION disorders; GENETIC disorders; CHI-squared test; LIPID metabolism disorders; TUMORS; INSULIN resistance; OXIDATION-reduction reaction; DISEASE complications
- Publication
Cancer (0008543X), 1993, Vol 72, Issue 10, p3106
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19931115)72:10<3106::AID-CNCR2820721036>3.0.CO;2-G