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- Title
Maternal Human Leukocyte Antigen A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission.
- Authors
Mackelprang, Romel D.; Carrington, Mary; John-Stewart, Grace; Lohman-Payne, Barbara; Richardson, Barbra A.; Wamalwa, Dalton; Gao, Xiaojiang; Majiwa, Maxwel; Mbori-Ngacha, Dorothy; Farquhar, Carey
- Abstract
We examined associations between maternal human leukocyte antigen (HLA) and vertical human immunodeficiency virus type 1 (HIV-1) transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified by using sequence-specific oligonucleotide probes, and analyses were performed using logistic regression. Maternal HLA-A*2301 was associated with increased transmission risk before and after adjusting for maternal viral load (unadjusted: odds ratio [OR], 3.21; 95% confidence interval [CI], 1.42−7.27; P = .005; Pcorr = 0.04; adjusted: OR, 3.07; corr 95% CI, 1.26−7.51; Pcorr = .01; P is not significant). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load.
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 8, p1273
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/656318