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- Title
Transport of [sup 14]C-deferiprone in normal, thalassaemic and sickle red blood cells.
- Authors
S, O; H, D; N, P; H, R; H, V; Shalev, Oded
- Abstract
The transport of deferiprone (L1) in normal (N), sickle (S) and thalassaemic (T) red blood cells (RBC) was determined by incubation with 14C-L1 at 37°C. Following incubation with 0.5 mm 14C-L1 for 4 h, the intracellular concentration of L1 in T RBC was 3 times higher than was found extracellularly. In contrast, no concentration gradient across N and S RBC membranes was detected. Efflux studies showed that T RBC released only 17 ± 2% of 14C-L1 into the extracellular space. We hypothesize that L1 accumulation in T RBC results from their high content of chelatable iron and formation of large, hydrophilic L1–Fe(III) complexes trapped within the cytosol.
- Subjects
THERAPEUTIC use of iron chelates; ERYTHROCYTES; SICKLE cell anemia; THALASSEMIA; PATHOLOGICAL physiology
- Publication
British Journal of Haematology, 1999, Vol 105, Issue 4, p1081
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1999.01447.x