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- Title
Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26).
- Authors
Gangaraju, Radhika; Carroll, Andrew J.; Prchal, Josef T.
- Abstract
Chromosomal inv(3)(q21q26)/t(3;3)(q21;q26) is a distinctive entity of acute myeloid leukemia (AML) with recurrent genetic abnormalities, occurring in about 2% of patients with AML [[1]]. We report a patient with essential thrombocythemia (ET) with inv(3), who achieved ongoing, prolonged hematologic remission and decreased inv(3)% with pegylated interferon-alfa 2a (IFN) treatment. Unlike the aggressive clinical course seen in reported patients with inv(3), our patient is doing exceptionally well with IFN treatment and continues to be in hematologic remission with persistence of the inv(3)(q21q26) clone.
- Subjects
THROMBOCYTOSIS; INTERFERONS; ACUTE myeloid leukemia; BONE marrow cells; CHRONIC myeloid leukemia; MYELOFIBROSIS
- Publication
Annals of Hematology, 2019, Vol 98, Issue 12, p2845
- ISSN
0939-5555
- Publication type
letter
- DOI
10.1007/s00277-019-03805-9