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- Title
Association Between Long-Term Lipid Profiles and Disease Severity in a Large Cohort of Patients with Inflammatory Bowel Disease.
- Authors
Koutroumpakis, Efstratios; Ramos-Rivers, Claudia; Regueiro, Miguel; Hashash, Jana; Barrie, Arthur; Swoger, Jason; Baidoo, Leonard; Schwartz, Marc; Dunn, Michael; Koutroubakis, Ioannis; Binion, David; Hashash, Jana G; Dunn, Michael A; Koutroubakis, Ioannis E; Binion, David G
- Abstract
<bold>Background: </bold>Inflammatory bowel disease (IBD) has been linked to an increased risk of coronary heart disease and stroke. Dyslipidemia is a well-established risk factor for cardiovascular disease. The aim of this study was to investigate the long-term lipid profiles in a large cohort of IBD patients.<bold>Methods: </bold>Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed. The lipid profiles of IBD patients were compared to those of the general population according to National Health and Nutrition Examination Survey (2009-2012). Quartiles of cholesterol or triglyceride levels in relation to surrogate markers of disease severity were analyzed.<bold>Results: </bold>Seven hundred and one IBD patients [54% Crohn's disease (CD), 46% ulcerative colitis (UC)] were included. IBD patients had less frequent high total cholesterol and high LDL cholesterol (6 vs. 13 and 5 vs. 10%) and more frequent low HDL and high triglycerides (24 vs. 17 and 33 vs. 25%) compared to the general population (all p < 0.001). Median total cholesterol levels were lower and median triglycerides higher in CD compared to UC (171 vs. 184; 123 vs. 100 mg/dL; both p < 0.001). In the multiple regression analysis, lipid profile was independently associated with hospitalizations (low cholesterol) and IBD surgeries (low cholesterol and high triglycerides).<bold>Conclusions: </bold>Low total cholesterol and high triglyceride levels are more frequent in IBD patients (in particular CD) compared to healthy controls and are independently associated with more severe disease.
- Subjects
INFLAMMATORY bowel diseases; DYSLIPIDEMIA; DATA analysis; COHORT analysis; HEALTH &; Nutrition Examination Survey; FOLLOW-up studies (Medicine); DISEASE risk factors; CROHN'S disease; HIGH density lipoproteins; HYPERLIPIDEMIA; LONGITUDINAL method; LOW density lipoproteins; QUESTIONNAIRES; REGRESSION analysis; TRIGLYCERIDES; ULCERATIVE colitis; ACQUISITION of data; SEVERITY of illness index; CASE-control method
- Publication
Digestive Diseases & Sciences, 2016, Vol 61, Issue 3, p865
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-015-3932-1